Calvin and Hobbes is a daily American comic strip created by cartoonist Bill Watterson that was syndicated from November 18, 1985, to December 31, 1995. Commonly cited as "the last great newspaper comic", Calvin and Hobbes has enjoyed broad and enduring popularity, influence, and academic and philosophical interest.

Calvin and Hobbes follows the humorous antics of the title characters: Calvin, a precocious, mischievous, and adventurous six-year-old boy; and Hobbes, his sardonic stuffed tiger. Set in the contemporary suburban United States of the 1980s and 90s, the strip depicts Calvin's frequent flights of fancy and friendship with Hobbes. It also examines Calvin's relationships with his long-suffering parents and with his classmates, especially his neighbor Susie Derkins. Hobbes' dual nature is a defining motif for the strip: to Calvin, Hobbes is a living anthropomorphic tiger, while all the other characters see Hobbes as an inanimate stuffed toy. Though the series does not frequently mention specific political figures or contemporary events, it does explore broad issues like environmentalism, public education, and philosophical quandaries.

At the height of its popularity, Calvin and Hobbes was featured in over 2,400 newspapers worldwide. In 2010, reruns of the strip appeared in more than 50 countries, and nearly 45 million copies of the Calvin and Hobbes books had been sold worldwide.